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What is Estradiol? Estradiol (E2), also known as estradiol, is an estrogenic steroid hormone and the most important female sex hormone. It is involved in female reproductive estrus and regulation of the menstrual cycle. Estradiol is involved in the development of female secondary sex characteristics, such as breast, hip enlargement, and fat distribution patterns in women.Reproductive tissues in women such as the mammary glands, uterus, and vagina during puberty, adulthood, and pregnancy. It also has important effects on many other tissues, including bone, fat, skin, liver, and brain. Why is Estradiol Used? As a drug, estradiol is used primarily in hormone therapy for menopausal symptoms and in transgender hormone replacement therapy. You can read here to find out about the full medical use of estradiol   Estradiol Levels Estrogen is a hormone that refers to the female reproductive hormone estradiol. It is a commonly found hormone in the body. The hormone is best recognized as the pre